Arizona Cardinals running back Andre Ellington is likely to miss his second straight game, according to the team's updated injury report for its matchup with the San Francisco 49ers on Sunday.
Ellington, who suffered a mild PCL sprain in the fourth quarter of the Cards' Week 1 victory over the Saints, is listed as doubtful for Sunday.
Cardinals coach Bruce Arians said Chris Johnson will once again start in Ellington's place if necessary. Johnson rushed for 72 yards on 20 carries in the Cards' road win over the Bears last weekend.
After missing the Cardinals' first two games of the regular season with a knee injury, guard Mike Iupati is questionable to play Sunday against his former team. A three-time Pro Bowler with the 49ers, Iupati signed a five-year contract with the Cards during the offseason.
Cardinals safeties Deone Bucannon (groin) and Tony Jefferson (hamstring), along with linebackers Alex Okafor (shoulder) and LaMarr Woodley (shoulder), are listed as probable for Sunday.
As expected, rookie wide receiver J.J. Nelson has been ruled out for Sunday with a shoulder injury. Arians said Monday that Nelson will likely miss 2 to 4 weeks of action.
On the 49ers side, running back Reggie Bush is listed as doubtful with a calf injury, while wide receiver Bruce Ellington (ankle) and tight end Vance McDonald (knee) are questionable.
Wide receiver Torrey Smith (knee), running back Carlos Hyde (quad), tight end Blake Bell (back), guard Alex Boone (shoulder) and linebacker Navorro Bowman (non-injury-related) are probable for Sunday.