The Arizona Cardinals will be down a running back and an offensive lineman, and possibly a pair of safeties, for their matchup Sunday at the Chicago Bears.
The Bears, meanwhile, may be without their star wide receiver.
On Friday, Cardinals coach Bruce Arians said starting running back Andre Ellington will not make the trip with the team to Chicago. Ellington was expected to miss Sunday's game and may be sidelined for an additional 1 to 2 weeks with a mild PCL sprain suffered in the fourth quarter of the Cards' win over the Saints last Sunday.
Three-time Pro Bowl guard Mike Iupati will not make the trip, either. Iupati, whom the Cardinals acquired from the 49ers in the offseason, suffered a knee injury during training camp. He may be ready to play in time for the Cards' home game against the 49ers next week.
Arians said safeties Deone Bucannon and Tony Jefferson will be game-time decisions Sunday. Bucannon is nursing a groin injury, while Jefferson is dealing with a hamstring injury. Both men played last week against the Saints.
On the Bears side, wide receiver Alshon Jeffery (hamstring) will also likely be a game-time call. If he plays, he's expected to match up with four-time Pro Bowl cornerback Patrick Peterson.
Bears cornerback Tracy Porter and linebacker Jonathan Bostic have been ruled out for Sunday. Defensive lineman Ego Ferguson and linebacker Pernell McPhee are questionable to play.