Crews responded to a crash near the Interstate 10/Interstate 17 stack interchange Friday afternoon.
Arizona Department of Public Safety Trooper Kameron Lee said a semi and three other vehicles where involved. Some of those inside suffered minor injuries.
The crash closed the eastbound ramp from I-10 to I-17 and caused gas to leak from the semi.
Authorities were on the scene working to get it cleaned up.
The Arizona Department of Transportation said traffic headed east on I-10 was restricted to the left two lanes.
The area was reopened to traffic around 5:30 p.m., according to the Arizona Department of Transportation.