Three people are in the hospital, including the driver a pickup truck who was going the wrong way on Interstate 17.
The incident happened around 11:15 p.m. Monday near Anthem.
According to DPS troopers on the scene, Fermin M. Cervantes, the pickup truck driver, was southbound in the northbound lanes of I-17 when he slammed head-on into an older couple.
The innocent couple driving a Subaru suffered non-life threatening injuries according to investigators.
The 51-year-old truck driver suffered minor injuries and was taken the hospital for further evaluation.
Arizona Department of Public Safety troopers believe the driver of the Ford F-150 pickup truck may have been impaired and drove about three miles in the wrong direction before the collision.
Cervantes was charged with aggravated assault, endangerment, criminal damaged and aggravated DUI.