Interstate 17 northbound was closed for several hours Tuesday morning near State Route 74 (Carefree Highway) after a wrong-way crash.
Arizona Department of Public Safety officials say the crash occurred around 5:20 a.m. Tuesday just north of Carefree Highway.
A passenger car was reportedly traveling southbound in the northbound lanes when it struck a semi-truck. The driver's sides of both vehicles made impact.
DPS says the driver of the passenger car, a woman in her twenties, was taken to the hospital with serious injuries after being ejected from the vehicle.
The semi-truck driver was not hurt.
Impairment is believed to be a factor in the crash.