Interstate 17 southbound was closed for approximately one hour due to a "law enforcement situation" near Jomax Road, according to the Arizona Department of Transportation.
The closure began around 9:30 Sunday night.
Arizona Department of Public Safety officials said the incident involved a commercial truck driver who claimed people had climbed into his trailer to damage the load.
Troopers conducted a high-risk stop and the driver exited the cab, saying two armed men were barricaded inside.
Multiple law enforcement and SWAT teams were called to the scene in an effort to resolve the situation.
During the investigation, the driver changed his story multiple times and it was ultimately discovered that no one else was in the vehicle.
The driver was investigated and arrested for DUI. He was identified as a 22-year-old from Colorado.
I-17 northbound was also temporarily closed.