Each day, they live in fear.
Sometimes it's the fear of rockets dropping from the sky. Sometimes it's violent fundamentalist militants taking over their cities.Sometimes it's the barrel bombs stuffed with TNT and nails.
Exactly what horror they face depends on which border they live within.
Syria, Iraq, Israel, Gaza and Libya.
Each with its unique crisis, but all now unified in a heightened sense of anxiety as years of conflict come to a head.
"I would argue," said U.S. Sen. John McCain said this week, "that, given conditions in the Middle East, this might be more dangerous than any time in the past."
Here's where the crises stand:
Assad wins ... again
With carnage mounting every day across the country, it's hard to find reason to celebrate in Syria.
And yet, President Bashar al-Assad and his supporters find a way. On Wednesday, al-Assad will be sworn in for his third term. It's an outcome pretty much everyone expected -- not because he is popularly adored, but because his family has ruled Syria since 1971. And no real contender ran against him.
Three years of civil war have left much of the country in shambles. While regime helicopters drop barrel bombs on opposition neighborhoods, dissidents say, the government maintains its stance that it's only fighting terrorists.
As if the civil war wasn't enough, the radical Sunni group Islamic State in Iraq in Syria is using this opportunity to carve its own swath of territory from the Iraq border to deep inside Syria.
The United Nations says more than 150,000 people have been killed in the past three years. But at this point, many have stopped counting.
"No one is winning; no one can win," U.N. Secretary-General Ban Ki-moon said. "Even if one side were to prevail in the short term, the devastating toll will have sown the seeds of future conflict."
Why we should care:
For Americans thinking the Syrian crisis doesn't hit home, think again.
U.S. intelligence and law enforcement have dozens of investigations under way, tracking Americans who traveled to Syria to join the fight.
"The FBI and other members of the intelligence community have made this a top priority and are taking whatever steps they can under the law to monitor and prevent those coming back from doing us harm," Assistant Attorney General John Carlin said.
Threat of fundamentalism looms
This month was supposed mark Iraq's first steps toward a new government. But it's hard to tout political gains when ISIS militants keep barreling across the country, snatching entire cities and threatening to take over Baghdad.
ISIS now controls land on both sides of the Iraq-Syria border -- opening the floodgates for weapons and fighters between the two countries.
On Wednesday, Iraqi security forces had to withdraw from central Tikrit after fierce fighting with militants believed to be ISIS members. At least 52 Iraqi security forces were killed.
Now, an unlikely pair of countries are coming to assist the embattled government -- the United States and Iran.
While U.S. advisors are on the ground assisting the regime, Iraq is increasingly relying on Iranian-backed Shiite militias to stave off radical Sunni ISIS militants -- especially around the capital.
Why we should care:
Former U.S. Vice President Dick Cheney said the crisis in Iraq now involves throngs of foreigners -- including Americans.
"One of the problems you have is a caliphate that includes part of Iraq, and you've got literally thousands of jihadist wannabes flooding into that part of the world from Europe -- some of them from the United States -- who want to participate in that conflict," Cheney told CNN's Jake Tapper.
"It's a threat to the United States, not just that part of the world."
ISRAEL AND GAZA
Retaliations and recrimination
What was supposed to be a cease-fire between Israeli forces and Palestinian militant group Hamas this week now seems like a joke.
Rockets fired by Hamas on Tuesday were quickly matched by airstrikes from Israel.
And so the exchanges continue.
Now, a leading member of Hamas says he's not opposed to peace -- but says there needs to be more compromise.
"We hope we can achieve a cease-fire -- but a cease-fire which can protect the Palestinians and guarantee that there will be no violations," Hamas spokesman Osama Hamdan said.
Israel, which accepted a cease-fire proposal by Egypt, defended its decision to strike back against Hamas.
"Instead of having this door open to a diplomatic solution, they closed the door," said Mark Regev, spokesman for the Israeli prime minister. "We now have to unfortunately protect our people through military means."
While both rockets and rhetoric fly, Human Rights Watch said Israeli air attacks have been "killing civilians in violation of the laws of war."
An Israeli military spokesman said civilian casualties in Gaza are "a human tragedy" -- but that it's Hamas' fault. The military accuses Hamas of taking civilians hostage by using places like houses, hospitals and schools to hide weapons.
More than 200 people
have been killed in Gaza since the offensive started a week ago, Palestinian officials said. One Israeli has also died.
Why we should care:
Many credit Israel's Iron Dome for saving untold lives on the Israeli side. In 2014, the United States provided $235 million for Iron Dome research, development and production, according to the Congressional Research Service.
Israel is also the biggest recipient of U.S. foreign aid, much of which has gone toward Israel's military spending.
U.S. Secretary of State John Kerry say's he'll return to the region if a cease-fire doesn't materialize.
"I am prepared to fly back to the region tomorrow, if I have to, or the next day, or the next, in order to pursue the prospects if this doesn't work," Kerry said. "But they deserve, the Egyptians deserve the time and the space to be able to try to make this initiative work."
Chief Palestinian negotiator Saeb Erakat put it bluntly: "We need the United States."
"Now the region is really boiling," he said. "Failure is not an option here."